Title : Metformin acts to suppress β-hydroxybutyric acid-mediated inflammatory responses through activation of AMPK signaling in bovine hepatocytes.

Pub. Date : 2021 Jul 1

PMID : 33982074






1 Functional Relationships(s)
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1 Along with the upregulation of phosphorylated AMPKalpha and ACCalpha, metformin at 1.5 and 3 mM inactivated NF-kappaB signalling components (p65 and IkappaBalpha) and the inflammatory genes (TNFA, IL6, IL1B and COX-2) which were activated by BHBA. Metformin acetyl-CoA carboxylase alpha Bos taurus