Pub. Date : 2021
PMID : 33981605
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Mutations in IDH lead to loss of normal enzymatic activity and gain of neomorphic activity that irreversibly converts alpha-KG to 2-hydroxyglutarate (2-HG), which can competitively inhibit a-KG-dependent enzymes, subsequently induces cell metabolic reprograming, inhibits cell differentiation, and initiates cell tumorigenesis. | alpha-hydroxyglutarate | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
2 | Mutations in IDH lead to loss of normal enzymatic activity and gain of neomorphic activity that irreversibly converts alpha-KG to 2-hydroxyglutarate (2-HG), which can competitively inhibit a-KG-dependent enzymes, subsequently induces cell metabolic reprograming, inhibits cell differentiation, and initiates cell tumorigenesis. | alpha-hydroxyglutarate | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |