Title : Biological Roles and Therapeutic Applications of IDH2 Mutations in Human Cancer.

Pub. Date : 2021

PMID : 33981605






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Mutations in IDH lead to loss of normal enzymatic activity and gain of neomorphic activity that irreversibly converts alpha-KG to 2-hydroxyglutarate (2-HG), which can competitively inhibit a-KG-dependent enzymes, subsequently induces cell metabolic reprograming, inhibits cell differentiation, and initiates cell tumorigenesis. alpha-hydroxyglutarate isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens
2 Mutations in IDH lead to loss of normal enzymatic activity and gain of neomorphic activity that irreversibly converts alpha-KG to 2-hydroxyglutarate (2-HG), which can competitively inhibit a-KG-dependent enzymes, subsequently induces cell metabolic reprograming, inhibits cell differentiation, and initiates cell tumorigenesis. alpha-hydroxyglutarate isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens