Pub. Date : 2021 Sep
PMID : 33969575
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Amplification of DDR2 mediates Sorafenib resistance through NF-kappaB/c-Rel signaling in hepatocellular carcinoma. | Sorafenib | discoidin domain receptor tyrosine kinase 2 | Homo sapiens |
| 2 | The effects of DDR2 on Sorafenib resistance were examined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), colony formation, TdT-mediated dUTP nick end labeling (TUNEL), and flow cytometry assays. | Sorafenib | discoidin domain receptor tyrosine kinase 2 | Homo sapiens |
| 3 | We demonstrated that DDR2 expression was dramatically upregulated in Sorafenib-resistant HCC tissues relative to sensitive tissues. | Sorafenib | discoidin domain receptor tyrosine kinase 2 | Homo sapiens |
| 4 | Downregulation of DDR2 sensitized HCC cell lines to Sorafenib cytotoxicity. | Sorafenib | discoidin domain receptor tyrosine kinase 2 | Homo sapiens |
| 5 | Our results demonstrated that DDR2 is a potential therapeutic target in patients with HCC, and targeting DDR2 represents a promising approach to increase Sorafenib sensitivity in patients with HCC. | Sorafenib | discoidin domain receptor tyrosine kinase 2 | Homo sapiens |