Title : miR-21 in EVs from pulmonary epithelial cells promotes myofibroblast differentiation via glycolysis in arsenic-induced pulmonary fibrosis.

Pub. Date : 2021 Oct 1

PMID : 33965804






2 Functional Relationships(s)
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1 After MRC-5 cells were co-cultured with arsenite-treated HBE cells, the levels of miR-21, AKT activation, glycolysis, and myofibroblast differentiation were enhanced, effects that were blocked by reducing miR-21 and by inhibiting the EVs in HBE cells. arsenite AKT serine/threonine kinase 1 Homo sapiens
2 Thus, miR-21 down-regulates PTEN and promotes glycolysis via activating AKT, which is associated with arsenite-induced myofibroblast differentiation and pulmonary fibrosis. arsenite AKT serine/threonine kinase 1 Homo sapiens