Pub. Date : 2021
PMID : 33965587
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mechanistically, the synergistic actions of GSK672 and FGF15 on inhibiting gut bile acid re-uptake and hepatic bile acid synthesis achieve greater magnitude of bile acid pool reduction that not only decreases bile acid burden in NASH livers but also limits intestinal lipid absorption, which, together with FGF15 signaling activation, produces weight loss, reduction of adipose inflammation, and attenuated hepatocellular organelle stress. | Bile Acids and Salts | fibroblast growth factor 15 | Mus musculus |
| 2 | Mechanistically, the synergistic actions of GSK672 and FGF15 on inhibiting gut bile acid re-uptake and hepatic bile acid synthesis achieve greater magnitude of bile acid pool reduction that not only decreases bile acid burden in NASH livers but also limits intestinal lipid absorption, which, together with FGF15 signaling activation, produces weight loss, reduction of adipose inflammation, and attenuated hepatocellular organelle stress. | Bile Acids and Salts | fibroblast growth factor 15 | Mus musculus |
| 3 | Mechanistically, the synergistic actions of GSK672 and FGF15 on inhibiting gut bile acid re-uptake and hepatic bile acid synthesis achieve greater magnitude of bile acid pool reduction that not only decreases bile acid burden in NASH livers but also limits intestinal lipid absorption, which, together with FGF15 signaling activation, produces weight loss, reduction of adipose inflammation, and attenuated hepatocellular organelle stress. | Bile Acids and Salts | fibroblast growth factor 15 | Mus musculus |
| 4 | Mechanistically, the synergistic actions of GSK672 and FGF15 on inhibiting gut bile acid re-uptake and hepatic bile acid synthesis achieve greater magnitude of bile acid pool reduction that not only decreases bile acid burden in NASH livers but also limits intestinal lipid absorption, which, together with FGF15 signaling activation, produces weight loss, reduction of adipose inflammation, and attenuated hepatocellular organelle stress. | Bile Acids and Salts | fibroblast growth factor 15 | Mus musculus |
| 5 | Furthermore, the combined treatment attenuates increased fecal bile acid excretion and repressed bile acid synthesis, which underlie diarrhea and hypercholesterolemia associated with ASBT inhibition and FGF19 analogue, respectively, in clinical settings. | Bile Acids and Salts | fibroblast growth factor 15 | Mus musculus |