Title : The ameliorative effect of niclosamide on bile duct ligation induced liver fibrosis via suppression of NOTCH and Wnt pathways.

Pub. Date : 2021 Sep 1

PMID : 33961984






1 Functional Relationships(s)
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1 Niclosamide (5 and 10 mg/kg) also significantly reduced NOTCH pathway (Jagged1, NOTCH2, NOTCH3, HES1, SOX9), Wnt pathway (Wnt5B, and Wnt10A), and fibrosis (transforming growth factor-beta1 (TGF-beta1), alpha smooth muscle actin (alpha-SMA) and collagen deposition with more prominent effect of the higher dose 10 mg/kg. Niclosamide SRY-box transcription factor 9 Rattus norvegicus