Title : Novel CTRP8-RXFP1-JAK3-STAT3 axis promotes Cdc42-dependent actin remodeling for enhanced filopodia formation and motility in human glioblastoma cells.

Pub. Date : 2022 Jan

PMID : 33960104






1 Functional Relationships(s)
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1 The Cdc42 mediated F-actin remodeling and pro-migratory action of the novel RXFP1-JAK3-STAT3-Cdc42 axis was blocked by JAK3 inhibitor Tofacitinib and STAT3 inhibitor S3I-201 and provides a new rationale for the design of JAK3 and STAT3 inhibitors with better brain permeability for clinical treatment of the pervasive brain invasiveness of GBM. tofacitinib signal transducer and activator of transcription 3 Homo sapiens