Title : A combination of phenobarbital and the bumetanide derivative bumepamine prevents neonatal seizures and subsequent hippocampal neurodegeneration in a rat model of birth asphyxia.

Pub. Date : 2021 Jun

PMID : 33955541






2 Functional Relationships(s)
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1 This suggestion was based on the idea that bumetanide, by reducing intraneuronal chloride accumulation through inhibition of the Na-K-2Cl cotransporter NKCC1, may attenuate or abolish depolarizing gamma-aminobutyric acid (GABA) responses caused by birth asphyxia. gamma-Aminobutyric Acid solute carrier family 12 member 2 Rattus norvegicus
2 This suggestion was based on the idea that bumetanide, by reducing intraneuronal chloride accumulation through inhibition of the Na-K-2Cl cotransporter NKCC1, may attenuate or abolish depolarizing gamma-aminobutyric acid (GABA) responses caused by birth asphyxia. gamma-Aminobutyric Acid solute carrier family 12 member 2 Rattus norvegicus