Title : Molecular determinants for recognition of RU 24969 analogs at central 5-hydroxytryptamine recognition sites: use of a bilinear function and substituent volumes to describe steric fit.

Pub. Date : 1988 Jul

PMID : 3393140






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The parameter of the indole-5 substituent that almost exclusively determines potency for 5-HT1A sites is volume, the optimal size being about 24 cubic angstroms (calculated by fitting the activity versus volume data to a bilinear function). indole 5-hydroxytryptamine receptor 1A Homo sapiens