Pub. Date : 2021 Apr 27
PMID : 33925488
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The effect of combination treatment with SB431542, a specific inhibitor of the transforming growth factor (TGF)-beta receptor kinase, and siRNA mediated knockdown of programmed cell death protein ligand-1 (PD-L1) on Sorafenib resistance was examined using a cell viability assay. | Sorafenib | CD274 molecule | Homo sapiens |
| 2 | The effect of combination treatment with SB431542, a specific inhibitor of the transforming growth factor (TGF)-beta receptor kinase, and siRNA mediated knockdown of programmed cell death protein ligand-1 (PD-L1) on Sorafenib resistance was examined using a cell viability assay. | Sorafenib | CD274 molecule | Homo sapiens |
| 3 | Following Sorafenib exposure, increase in the expression of PD-L1 and other immune checkpoints was observed. | Sorafenib | CD274 molecule | Homo sapiens |
| 4 | Moreover, the sensitivity of HCC cells to Sorafenib was enhanced by combining a blockade of EMT with SB431542 and knockdown of PD-L1 expression. | Sorafenib | CD274 molecule | Homo sapiens |
| 5 | Sorafenib-induced motility was attenuated with the combined treatment of SB431542 and PD-L1 knockdown. | Sorafenib | CD274 molecule | Homo sapiens |