Pub. Date : 2021 Apr 21
PMID : 33919366
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Enhanced Palmitate-Induced Interleukin-8 Formation in Human Macrophages by Insulin or Prostaglandin E2. | Dinoprostone | C-X-C motif chemokine ligand 8 | Homo sapiens |
2 | The current study addressed the question of how palmitate might interact with insulin or PGE2 to induce the formation of the chemotactic pro-inflammatory cytokine interleukin-8 (IL-8). | Dinoprostone | C-X-C motif chemokine ligand 8 | Homo sapiens |
3 | The current study addressed the question of how palmitate might interact with insulin or PGE2 to induce the formation of the chemotactic pro-inflammatory cytokine interleukin-8 (IL-8). | Dinoprostone | C-X-C motif chemokine ligand 8 | Homo sapiens |
4 | PGE2 in turn elicited IL-8 formation on its own and enhanced the induction of IL-8 release by palmitate, most likely by activating the EP4 receptor. | Dinoprostone | C-X-C motif chemokine ligand 8 | Homo sapiens |
5 | PGE2 in turn elicited IL-8 formation on its own and enhanced the induction of IL-8 release by palmitate, most likely by activating the EP4 receptor. | Dinoprostone | C-X-C motif chemokine ligand 8 | Homo sapiens |
6 | Since IL-8 causes insulin resistance and fosters inflammation, the increase in palmitate-induced IL-8 formation that is caused by hyperinsulinemia and locally produced PGE2 in chronically inflamed adipose tissue might favor disease progression in a vicious feed-forward cycle. | Dinoprostone | C-X-C motif chemokine ligand 8 | Homo sapiens |