Title : Pathological polyQ expansion does not alter the conformation of the Huntingtin-HAP40 complex.

Pub. Date : 2021 Aug 5

PMID : 33909994






5 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 At the protein level, this translates into the expansion of a polyglutamine (polyQ) stretch located at the HTT N terminus, which renders HTT aggregation prone by unknown mechanisms. polyglutamine huntingtin Homo sapiens
2 At the protein level, this translates into the expansion of a polyglutamine (polyQ) stretch located at the HTT N terminus, which renders HTT aggregation prone by unknown mechanisms. polyglutamine huntingtin Homo sapiens
3 At the protein level, this translates into the expansion of a polyglutamine (polyQ) stretch located at the HTT N terminus, which renders HTT aggregation prone by unknown mechanisms. polyglutamine huntingtin Homo sapiens
4 At the protein level, this translates into the expansion of a polyglutamine (polyQ) stretch located at the HTT N terminus, which renders HTT aggregation prone by unknown mechanisms. polyglutamine huntingtin Homo sapiens
5 Here we investigated the effects of polyQ expansion on HTT in a complex with its stabilizing interaction partner huntingtin-associated protein 40 (HAP40). polyglutamine huntingtin Homo sapiens