Title : Aldosterone up-regulates basolateral Na+ -K+ -2Cl- cotransporter-1 to support enhanced large-conductance K+ channel-mediated K+ secretion in rat distal colon.

Pub. Date : 2021 May

PMID : 33908679






1 Functional Relationships(s)
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1 Aldosterone enhanced NKCC1 and BKalpha expression and electrogenic K+ secretion in the distal colon, which was inhibited by either serosal bumetanide (NKCC1 inhibitor) or mucosal iberiotoxin (IbTX; BK channel blocker), but not TRAM-34 (IK channel blocker). Bumetanide solute carrier family 12 member 2 Rattus norvegicus