Title : A high-androgen microenvironment inhibits granulosa cell proliferation and alters cell identity.

Pub. Date : 2021 Jul 1

PMID : 33905753






1 Functional Relationships(s)
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1 Granulosa cell culture confirmed that A4 treatment decreased GC proliferation, increased anti-Mullerian hormone, and increased mRNA for CTNNBIP1, which prevents CTNNB1 from interacting with members of the WNT signaling pathway thereby inhibiting the cell cycle.Expression of CYP17A1 was upregulated in High A4 GCs presumably due to reduced FOS mRNA expression compared to Control granulosa cells. a4 Fos proto-oncogene, AP-1 transcription factor subunit Bos taurus