Title : Affinity Selections of DNA-Encoded Chemical Libraries on Carbonic Anhydrase IX-Expressing Tumor Cells Reveal a Dependence on Ligand Valence.

Pub. Date : 2021 Jun 21

PMID : 33905156






1 Functional Relationships(s)
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1 Salt concentration and performing PCR on cell suspension had the biggest impact on selection performance, leading to 15-fold enrichment factors for high-affinity monovalent CAIX binders (acetazolamide; K D = 8.7 nM). Acetazolamide carbonic anhydrase 9 Homo sapiens