Title : Distinct Response to Platinum-Based Chemotherapy among Patients with Metastatic Castration-Resistant Prostate Cancer Harboring Alterations in Genes Involved in Homologous Recombination.

Pub. Date : 2021 Sep

PMID : 33904759






1 Functional Relationships(s)
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1 Patients with mCRPC harboring genomic defects in crucial HR genes either in the germline or somatic, especially BRCA2 and ATM, might experience superior outcomes to platinum-based chemotherapy, compared with those harboring CDK12 defect. Platinum ATM serine/threonine kinase Homo sapiens