Title : Dual nature of human ACE2 glycosylation in binding to SARS-CoV-2 spike.

Pub. Date : 2021 May 11

PMID : 33903171






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Interestingly, the glycans at two glycosylation sites, N90 and N322, have opposite effects on spike protein binding. Polysaccharides surface glycoprotein Severe acute respiratory syndrome coronavirus 2
2 Therefore, this glycan can interfere with the binding of the spike protein and protect against docking of the virus to the cell. Polysaccharides surface glycoprotein Severe acute respiratory syndrome coronavirus 2
3 By contrast, the glycan at the N322 site interacts tightly with the RBD of the ACE2-bound spike protein and strengthens the complex. Polysaccharides surface glycoprotein Severe acute respiratory syndrome coronavirus 2