Title : Pitavastatin and metformin synergistically activate apoptosis and autophagy in pancreatic cancer cells.

Pub. Date : 2021 Aug

PMID : 33886150






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1 We found that cotreatment with metformin (30 mM) and pitavastatin (10 muM) significantly reduced cell viability; caused G0/G1 cell cycle arrest; upregulated the expression levels of Bax, PCNA, cleaved PARP-1, cleaved caspase-3, LC3 II, and p27 Kip1 /p21Cip1 ; and inhibited cell migration. Metformin caspase 3 Homo sapiens