Title : A new model for regulation of sphingosine kinase 1 translocation to the plasma membrane in breast cancer cells.

Pub. Date : 2021 Jan-Jun

PMID : 33865856






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We report here that monomeric wild type (WT) mouse SK1 (GFP-mSK1) translocates to the PM of MCF-7L cells stimulated with carbachol or phorbol myristate acetate (PMA), whereas the dimer translocates to the PM in response to sphingosine 1-phosphate (S1P); thus, the equilibrium between monomer and dimer is sensitive to cellular stimulus. sphingosine 1-phosphate sphingosine kinase 1 Mus musculus
2 We report here that monomeric wild type (WT) mouse SK1 (GFP-mSK1) translocates to the PM of MCF-7L cells stimulated with carbachol or phorbol myristate acetate (PMA), whereas the dimer translocates to the PM in response to sphingosine 1-phosphate (S1P); thus, the equilibrium between monomer and dimer is sensitive to cellular stimulus. sphingosine 1-phosphate sphingosine kinase 1 Mus musculus