Title : Azetidinimines as a novel series of non-covalent broad-spectrum inhibitors of β-lactamases with submicromolar activities against carbapenemases KPC-2 (class A), NDM-1 (class B) and OXA-48 (class D).

Pub. Date : 2021 Jul 5

PMID : 33862516






1 Functional Relationships(s)
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1 Despite the structural and mechanistic differences between serine-beta-lactamases KPC-2 and OXA-48 and metallo-beta-lactamase NDM-1, all three enzymes can be inhibited at a submicromolar level by compound 7dfm, which can also repotentiate imipenem against a resistant strain of Escherichia coli expressing NDM-1. Serine KPC-2 Escherichia coli