Title : Structure of human ORP3 ORD reveals conservation of a key function and ligand specificity in OSBP-related proteins.

Pub. Date : 2021

PMID : 33857182






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 ORP3 binds PI(4)P by the residues around tunnel entrance and in the hydrophobic pocket, whereas it lacks sterol binding due to the narrow hydrophobic tunnel. pi(4)p oxysterol binding protein like 3 Homo sapiens
2 In contrast, the PI(4)P-binding site mutant of ORP3 did not complement the OSH knockout cells. pi(4)p oxysterol binding protein like 3 Homo sapiens