Pub. Date : 2019 Jun
PMID : 33855492
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Feedback Regulation of Cathepsin C by the Propeptide Dipeptides of Granzymes A and B. | Dipeptides | cathepsin C | Homo sapiens |
| 2 | Granzymes A and B are activated by proteolytic removal of their N-terminal dipeptides by cathepsin C (dipeptidyl-peptidase I). | Dipeptides | cathepsin C | Homo sapiens |
| 3 | Granzymes A and B are activated by proteolytic removal of their N-terminal dipeptides by cathepsin C (dipeptidyl-peptidase I). | Dipeptides | cathepsin C | Homo sapiens |
| 4 | Cathepsin C is known to generate cytotoxic polymers from various dipeptides, however, in the case of the dipeptides Glu-Lys and Gly-Glu, cathepsin C was unable to polymerize them. | Dipeptides | cathepsin C | Homo sapiens |
| 5 | Cathepsin C is known to generate cytotoxic polymers from various dipeptides, however, in the case of the dipeptides Glu-Lys and Gly-Glu, cathepsin C was unable to polymerize them. | Dipeptides | cathepsin C | Homo sapiens |
| 6 | Cathepsin C is known to generate cytotoxic polymers from various dipeptides, however, in the case of the dipeptides Glu-Lys and Gly-Glu, cathepsin C was unable to polymerize them. | Dipeptides | cathepsin C | Homo sapiens |
| 7 | Unexpectedly the dipeptides were found to be inhibitors of the transferase activity of cathepsin C (IC50 < 20 mM), and weak competitive inhibitors of the peptidase activity with Ki values in the millimolar range. | Dipeptides | cathepsin C | Homo sapiens |
| 8 | This suggests that the dipeptides can play role in a feedback loop that controls transferase and proteolytic activities of cathepsin C in various biological processes. | Dipeptides | cathepsin C | Homo sapiens |