Pub. Date : 2021 Apr 13
PMID : 33852844
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Huntingtin-mediated axonal transport requires arginine methylation by PRMT6. | Arginine | huntingtin | Homo sapiens |
| 2 | To better understand how HTT mediates axonal transport and why this function is disrupted in Huntington"s disease (HD), we study vesicle-associated HTT and find that it is dimethylated at a highly conserved arginine residue (R118) by the protein arginine methyltransferase 6 (PRMT6). | Arginine | huntingtin | Homo sapiens |
| 3 | Arginine methylation thus regulates HTT-mediated vesicular transport along the axon, and increasing HTT methylation could be of therapeutic interest for HD. | Arginine | huntingtin | Homo sapiens |