Title : Metformin's Therapeutic Efficacy in the Treatment of Diabetes Does Not Involve Inhibition of Mitochondrial Glycerol Phosphate Dehydrogenase.

Pub. Date : 2021 Jul

PMID : 33849997






7 Functional Relationships(s)
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1 Metformin has beneficial effects in humans in tissues with high levels of mGPD such as pancreatic beta cells where mGPD is much higher than in liver. Metformin atypical chemokine receptor 1 (Duffy blood group) Mus musculus
2 Metformin has beneficial effects in humans in tissues with high levels of mGPD such as pancreatic beta cells where mGPD is much higher than in liver. Metformin atypical chemokine receptor 1 (Duffy blood group) Mus musculus
3 For these and other reasons we used four different enzyme assays to reassess whether metformin inhibited mGPD. Metformin atypical chemokine receptor 1 (Duffy blood group) Mus musculus
4 If metformin actually inhibited mGPD, adverse effects in tissues where the level of mGPD is much higher than in liver could prevent metformin"s use as a diabetes medicine. Metformin atypical chemokine receptor 1 (Duffy blood group) Mus musculus
5 If metformin actually inhibited mGPD, adverse effects in tissues where the level of mGPD is much higher than in liver could prevent metformin"s use as a diabetes medicine. Metformin atypical chemokine receptor 1 (Duffy blood group) Mus musculus
6 If metformin actually inhibited mGPD, adverse effects in tissues where the level of mGPD is much higher than in liver could prevent metformin"s use as a diabetes medicine. Metformin atypical chemokine receptor 1 (Duffy blood group) Mus musculus
7 If metformin actually inhibited mGPD, adverse effects in tissues where the level of mGPD is much higher than in liver could prevent metformin"s use as a diabetes medicine. Metformin atypical chemokine receptor 1 (Duffy blood group) Mus musculus