Title : pH-Triggered Copper-Free Click Reaction-Mediated Micelle Aggregation for Enhanced Tumor Retention and Elevated Immuno-Chemotherapy against Melanoma.

Pub. Date : 2021 Apr 21

PMID : 33834754






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1 To activate NK cell-based immuno-chemotherapy and enhance the tumor retention, we proposed a pH-responsive self-aggregated nanoparticle for the codelivery of chemotherapeutic doxorubicin (DOX) and the transforming growth factor-beta (TGF-beta)/Smad3 signaling pathway inhibitor SIS3. Doxorubicin tumor necrosis factor Homo sapiens
2 To activate NK cell-based immuno-chemotherapy and enhance the tumor retention, we proposed a pH-responsive self-aggregated nanoparticle for the codelivery of chemotherapeutic doxorubicin (DOX) and the transforming growth factor-beta (TGF-beta)/Smad3 signaling pathway inhibitor SIS3. Doxorubicin tumor necrosis factor Homo sapiens