Title : Clostridioides difficile toxins enhanced the in vitro production of CXC chemokine ligand 2 and tumor necrosis factor-α via Toll-like receptors in macrophages.

Pub. Date : 2021 Apr

PMID : 33830910






3 Functional Relationships(s)
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1 In RAW264.7 macrophages, CXCL2 and TNF-alpha were produced via the Toll-like receptor 2 (TLR2) or Toll-like receptor 4 (TLR4) pathway in a TcdA, TcdB, or CDT dose-dependent manner. 1,5,9-cyclododecatriene C-X-C motif chemokine ligand 2 Homo sapiens
2 Our results showed that C. difficile toxins, including CDT, enhanced macrophage-mediated CXCL2 and TNF-alpha production via TLR2 and TLR4, indicating that CDT affects host immune responses. 1,5,9-cyclododecatriene C-X-C motif chemokine ligand 2 Homo sapiens
3 Our results showed that C. difficile toxins, including CDT, enhanced macrophage-mediated CXCL2 and TNF-alpha production via TLR2 and TLR4, indicating that CDT affects host immune responses. 1,5,9-cyclododecatriene C-X-C motif chemokine ligand 2 Homo sapiens