Title : Hepcidin-induced reduction in iron content and PGC-1β expression negatively regulates osteoclast differentiation to play a protective role in postmenopausal osteoporosis.

Pub. Date : 2021 Apr 4

PMID : 33820875






3 Functional Relationships(s)
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1 Hepcidin-induced reduction in iron content and PGC-1beta expression negatively regulates osteoclast differentiation to play a protective role in postmenopausal osteoporosis. Iron hepcidin antimicrobial peptide Mus musculus
2 Hepcidin is a key regulator of iron homeostasis. Iron hepcidin antimicrobial peptide Mus musculus
3 These data showed that hepcidin protected osteoporosis by reducing iron levels in bone tissue, and in conjunction with PGC-1beta, reduced ROS production and the number of mitochondria, thus inhibiting osteoclast differentiation and bone absorption. Iron hepcidin antimicrobial peptide Mus musculus