Title : Arsenite induces tissue factor synthesis through Nrf2 activation in cultured human aortic smooth muscle cells.

Pub. Date : 2021

PMID : 33814512






2 Functional Relationships(s)
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1 We found that (1) arsenite stimulated TF synthesis and activated the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in HASMCs, (2) sulforaphane, an Nrf2 activator, also stimulated TF synthesis in HASMCs, and (3) arsenite-induced upregulation of TF synthesis was prevented by Nrf2 knockdown in HASMCs. sulforaphane coagulation factor III, tissue factor Homo sapiens
2 We found that (1) arsenite stimulated TF synthesis and activated the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in HASMCs, (2) sulforaphane, an Nrf2 activator, also stimulated TF synthesis in HASMCs, and (3) arsenite-induced upregulation of TF synthesis was prevented by Nrf2 knockdown in HASMCs. sulforaphane coagulation factor III, tissue factor Homo sapiens