Pub. Date : 2021 Jun 1
PMID : 33811821
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We show that glycine amidinotransferase (GATM), the rate-limiting enzyme for creatine synthesis, is upregulated in liver metastases. | Creatine | glycine amidinotransferase (L-arginine:glycine amidinotransferase) | Mus musculus |
| 2 | Dietary uptake, or GATM-mediated de novo synthesis of creatine, enhances cancer metastasis and shortens mouse survival by upregulation of Snail and Slug expression via monopolar spindle 1 (MPS1)-activated Smad2 and Smad3 phosphorylation. | Creatine | glycine amidinotransferase (L-arginine:glycine amidinotransferase) | Mus musculus |