Title : The Interactome between Metabolism and Gene Mutations in Myeloid Malignancies.

Pub. Date : 2021 Mar 19

PMID : 33808599






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 This is the case of IDH1/2 mutations generating the abnormal conversion of alpha-ketoglutarate (KG) to 2-hydroxyglutarate, an oncometabolite inhibiting KG-dependent enzymes, such as the TET family of genes (pivotal in characterizing leukemia cells either by mutations, e.g., TET2, or by altered expression, e.g., TET1/2/3). Ketoglutaric Acids isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens