Title : Neutrophil Adhesion and the Release of the Free Amino Acid Hydroxylysine.

Pub. Date : 2021 Mar 5

PMID : 33807594






1 Functional Relationships(s)
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1 Using amino acid analysis, mass spectrometry and electron microscopy, we found that the lysyl hydroxylase inhibitor minoxidil, the matrix metalloproteinase inhibitor doxycycline, the PI3K/Akt pathway inhibitors wortmannin and the Akt1/2 inhibitor and drugs that affect the actin cytoskeleton significantly and selectively block the release of hydroxylysine and partially or completely suppress spreading of neutrophils. Wortmannin AKT serine/threonine kinase 1 Homo sapiens