Pub. Date : 2021 Mar 4
PMID : 33806634
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Physiologically Based Pharmacokinetic Modeling of Bupropion and Its Metabolites in a CYP2B6 Drug-Drug-Gene Interaction Network. | Bupropion | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 2 | The noradrenaline and dopamine reuptake inhibitor bupropion is metabolized by CYP2B6 and recommended by the FDA as the only sensitive substrate for clinical CYP2B6 drug-drug interaction (DDI) studies. | Bupropion | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 3 | The noradrenaline and dopamine reuptake inhibitor bupropion is metabolized by CYP2B6 and recommended by the FDA as the only sensitive substrate for clinical CYP2B6 drug-drug interaction (DDI) studies. | Bupropion | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 4 | It incorporates CYP2B6-mediated hydroxylation of bupropion, metabolism via CYP2C19 and 11beta-HSD, as well as binding to pharmacological targets. | Bupropion | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |