Title : Sorafenib suppresses proliferation rate of fibroblast-like synoviocytes through the arrest of cell cycle in experimental adjuvant arthritis.

Pub. Date : 2021 Mar 1

PMID : 33791811






2 Functional Relationships(s)
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1 Also, sorafenib significantly decreased the levels of P21, CyclinD1, CDK4 and proliferating cell nuclear antigen, as well as up-regulated P53 expression in adjuvant arthritis fibroblast-like synoviocytes. Sorafenib Wistar clone pR53P1 p53 pseudogene Rattus norvegicus
2 CONCLUSIONS: Sorafenib could inhibit adjuvant arthritis fibroblast-like synoviocytes proliferation via arresting G1/S cell cycle progression, which was partially through CDK4/CyclinD1-mediated pathway, as well as up-regulating P53 and down-regulating proliferating cell nuclear antigen expressions. Sorafenib Wistar clone pR53P1 p53 pseudogene Rattus norvegicus