Title : Changes in expression of TLR-4, TGF-β, INF-γ, TNF-α in cultured T24/83 cells of invasive bladder cancer treated with cisplatin and/or polyphenolic adjuvant melanin.

Pub. Date : 2021 Mar

PMID : 33785718






3 Functional Relationships(s)
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1 Changes in expression of TLR-4, TGF-beta, INF-gamma, TNF-alpha in cultured T24/83 cells of invasive bladder cancer treated with cisplatin and/or polyphenolic adjuvant melanin. Cisplatin toll like receptor 4 Homo sapiens
2 RESULTS: Melanin, cisplatin, and their combination downregulate TLR4 expression (2.67; 1.28; and 2.73-fold decrease, respectively) and TNF-alpha expression (6.5; 1.4; and 1.7-fold decrease, respectively). Cisplatin toll like receptor 4 Homo sapiens
3 CONCLUSIONS: Melanin, cisplatin, and combination of both agents affect significantly TLR4, TNF-alpha, TGF-beta, INF-gamma expression, cell cycle distribution and morphology in T24/83 cells suggesting their transition to less aggressive phenotype. Cisplatin toll like receptor 4 Homo sapiens