Title : eIF4E-eIF4G complex inhibition synergistically enhances the effect of sorafenib in hepatocellular carcinoma.

Pub. Date : 2021 Sep 1

PMID : 33783376






1 Functional Relationships(s)
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1 Besides, the coadministration of sorafenib and 4E1RCat or 4EGI-1 synergistically inhibited the expressions of eIF4E, eIF4G and phospho-4E-BP1 in HCC cells while blocking the phosphorylation of 4E-BP1 with lentiviral transfection failed to increase the sensitivity of HCC cells to sorafenib treatment. Sorafenib eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens