Pub. Date : 2021 Jun 1
PMID : 33775835
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Discovery of N-Amido-Phenylsulfonamide Derivatives as Novel Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) Inhibitors. | Dinoprostone | prostaglandin E synthase | Mus musculus |
| 2 | Among them, MPO-0186 (scaffold C) inhibited the production of PGE2 (IC50: 0.24 muM) in A549 cells via inhibition of mPGES-1 (IC50: 0.49 muM in a cell-free assay) and was found to be approximately 9- and 8-fold more potent than MK-886 as a reference inhibitor, respectively. | Dinoprostone | prostaglandin E synthase | Mus musculus |
| 3 | A molecular docking study theoretically suggests that MPO-0186 could inhibit PGE2 production by blocking the PGH2 binding site of mPGES-1 enzyme. | Dinoprostone | prostaglandin E synthase | Mus musculus |