Pub. Date : 2022 Jan
PMID : 33772142
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | PPARalpha agonist fenofibrate relieves acquired resistance to gefitinib in non-small cell lung cancer by promoting apoptosis via PPARalpha/AMPK/AKT/FoxO1 pathway. | Fenofibrate | AKT serine/threonine kinase 1 | Homo sapiens |
2 | In PC-9/GR, H1975 and H1650 cells, fenofibrate dose-dependently increased the expression of AMPK, FoxO1, and decreased the expression of AKT, which were remarkably weakened by knockdown of PPARalpha. | Fenofibrate | AKT serine/threonine kinase 1 | Homo sapiens |