Title : PPARĪ± agonist fenofibrate relieves acquired resistance to gefitinib in non-small cell lung cancer by promoting apoptosis via PPARĪ±/AMPK/AKT/FoxO1 pathway.

Pub. Date : 2022 Jan

PMID : 33772142






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 PPARalpha agonist fenofibrate relieves acquired resistance to gefitinib in non-small cell lung cancer by promoting apoptosis via PPARalpha/AMPK/AKT/FoxO1 pathway. Fenofibrate AKT serine/threonine kinase 1 Homo sapiens
2 In PC-9/GR, H1975 and H1650 cells, fenofibrate dose-dependently increased the expression of AMPK, FoxO1, and decreased the expression of AKT, which were remarkably weakened by knockdown of PPARalpha. Fenofibrate AKT serine/threonine kinase 1 Homo sapiens