Title : MiR-221-3p-mediated downregulation of MDM2 reverses the paclitaxel resistance of non-small cell lung cancer in vitro and in vivo.

Pub. Date : 2021 May 15

PMID : 33771522






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 PTX increased miR-221-3p expression and regulated MDM2/P53 expression in the PTX-sensitive NSCLC strain (A549). Paclitaxel tumor protein p53 Homo sapiens
2 PTX increased miR-221-3p expression and regulated MDM2/P53 expression in the PTX-sensitive NSCLC strain (A549). Paclitaxel tumor protein p53 Homo sapiens
3 In conclusion, miR-221-3p overexpression could regulate MDM2/p53 signaling pathway to reverse the PTX resistance of NSCLC and induce apoptosis in vitro and vivo. Paclitaxel tumor protein p53 Homo sapiens