Pub. Date : 2021
PMID : 33767588
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | miR-26b enhances the sensitivity of hepatocellular carcinoma to Doxorubicin via USP9X-dependent degradation of p53 and regulation of autophagy. | Doxorubicin | tumor protein p53 | Homo sapiens |
2 | Delivery of the proteasome inhibitor, MG132, reversed the inhibitory effect of miR-26b on the level of p53 following doxorubicin treatment. | Doxorubicin | tumor protein p53 | Homo sapiens |
3 | Our current data indicate that miR-26b enhances HCC cell sensitivity to doxorubicin through diminishing USP9X-mediated p53 de-ubiquitination caused by DNA damaging drugs and autophagy regulation. | Doxorubicin | tumor protein p53 | Homo sapiens |