Pub. Date : 2021 May 1
PMID : 33760662
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Niemann-Pick C1 Like-1 (NPC1L1) mediates the uptake of micellar cholesterol by intestinal epithelial cells and is the molecular target of the cholesterol-lowering drug ezetimibe (EZE). | Cholesterol | NPC1 like intracellular cholesterol transporter 1 | Homo sapiens |
| 2 | Niemann-Pick C1 Like-1 (NPC1L1) mediates the uptake of micellar cholesterol by intestinal epithelial cells and is the molecular target of the cholesterol-lowering drug ezetimibe (EZE). | Cholesterol | NPC1 like intracellular cholesterol transporter 1 | Homo sapiens |
| 3 | Niemann-Pick C1 Like-1 (NPC1L1) mediates the uptake of micellar cholesterol by intestinal epithelial cells and is the molecular target of the cholesterol-lowering drug ezetimibe (EZE). | Cholesterol | NPC1 like intracellular cholesterol transporter 1 | Homo sapiens |
| 4 | Niemann-Pick C1 Like-1 (NPC1L1) mediates the uptake of micellar cholesterol by intestinal epithelial cells and is the molecular target of the cholesterol-lowering drug ezetimibe (EZE). | Cholesterol | NPC1 like intracellular cholesterol transporter 1 | Homo sapiens |
| 5 | The detailed mechanisms responsible for intracellular shuttling of micellar cholesterol is not fully understood due to the lack of a suitable NPC1L1-substrate that can be traced by fluorescence imaging and biochemical methods. | Cholesterol | NPC1 like intracellular cholesterol transporter 1 | Homo sapiens |
| 6 | These data show that alkyne cholesterol acts as a substrate for NPC1L1 and may serve as a non-radioactive tracer to measure cholesterol absorption in both in vitro and in vivo models. | Cholesterol | NPC1 like intracellular cholesterol transporter 1 | Homo sapiens |