Title : Bruton's agammaglobulinemia tyrosine kinase (Btk) regulates TPA‑induced breast cancer cell invasion via PLCγ2/PKCβ/NF‑κB/AP‑1‑dependent matrix metalloproteinase‑9 activation.

Pub. Date : 2021 May

PMID : 33760219






1 Functional Relationships(s)
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1 BTK inhibitors [ibrutinib (10 microM), CNX-774 (10 microM)] significantly attenuated TPA-induced cell invasion and migration in MCF-7 cells and inhibited the activation of the phospholipase Cgamma2/PKCbeta signaling pathways. ibrutinib Bruton tyrosine kinase Homo sapiens