Title : The mineral dust-induced gene, mdig, regulates angiogenesis and lymphangiogenesis in lung adenocarcinoma by modulating the expression of VEGF-A/C/D via EGFR and HIF-1α signaling.

Pub. Date : 2021 May

PMID : 33760153






1 Functional Relationships(s)
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1 In conclusion, mdig is an oxygen-sensitive protein that promotes tumor growth and angiogenesis by activating the EGFR/p-EGFR/VEGF-A/VEGF-R1/R2 pathway and inhibits lymphangiogenesis by blocking the HIF-1alpha/VEGF-C/D/VEGF-R3 pathway. Oxygen ribosomal oxygenase 2 Homo sapiens