Title : HK2 is associated with the Warburg effect and proliferation in liver cancer: Targets for effective therapy with glycyrrhizin.

Pub. Date : 2021 May

PMID : 33760124






2 Functional Relationships(s)
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1 A pronounced increase in the OCR, and decreases in the cell proliferation, glucose uptake capacity, lactic acid content, ECAR and HK2 expression were detected in LC cells subjected to GA treatment or HK2-knockdown. Gallium hexokinase 2 Homo sapiens
2 In conclusion, GA may inhibit the Warburg effect and cell proliferation in LC by suppressing HK2 through blockade of the PI3K/AKT signaling pathway. Gallium hexokinase 2 Homo sapiens