Pub. Date : 2021 Mar 23
PMID : 33758062
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | HN1L/JPT2: A signaling protein that connects NAADP generation to Ca2+ microdomain formation. | NAADP | Jupiter microtubule associated homolog 2 | Homo sapiens |
| 2 | In our characterization of the molecular machinery underlying NAADP action, we identified an NAADP-binding protein, called hematological and neurological expressed 1-like protein (HN1L) [also known as Jupiter microtubule-associated homolog 2 (JPT2)]. | NAADP | Jupiter microtubule associated homolog 2 | Homo sapiens |
| 3 | In our characterization of the molecular machinery underlying NAADP action, we identified an NAADP-binding protein, called hematological and neurological expressed 1-like protein (HN1L) [also known as Jupiter microtubule-associated homolog 2 (JPT2)]. | NAADP | Jupiter microtubule associated homolog 2 | Homo sapiens |
| 4 | Photoaffinity labeling demonstrated direct binding of NAADP to recombinant HN1L/JPT2. | NAADP | Jupiter microtubule associated homolog 2 | Homo sapiens |
| 5 | T cell receptor/CD3-dependent coprecipitation of HN1L/JPT2 with RYRs and colocalization of these proteins suggest that HN1L/JPT2 connects NAADP formation with the activation of RYR channels within the first seconds of T cell activation. | NAADP | Jupiter microtubule associated homolog 2 | Homo sapiens |
| 6 | T cell receptor/CD3-dependent coprecipitation of HN1L/JPT2 with RYRs and colocalization of these proteins suggest that HN1L/JPT2 connects NAADP formation with the activation of RYR channels within the first seconds of T cell activation. | NAADP | Jupiter microtubule associated homolog 2 | Homo sapiens |
| 7 | Thus, HN1L/JPT2 enables NAADP to activate Ca2+ release from the endoplasmic reticulum through RYR. | NAADP | Jupiter microtubule associated homolog 2 | Homo sapiens |