Title : Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection.

Pub. Date : 2021 Mar 19

PMID : 33741941






1 Functional Relationships(s)
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1 We further demonstrate that alpha1AT binds and inactivates the serine protease TMPRSS2, which enzymatically primes the SARS-CoV-2 spike protein for membrane fusion. Serine surface glycoprotein Severe acute respiratory syndrome coronavirus 2