Pub. Date : 2021 Aug 1
PMID : 33735117
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Enhanced anticancer activity by the combination of vinpocetine and sorafenib via PI3K/AKT/GSK-3beta signaling axis in hepatocellular carcinoma cells. | Sorafenib | glycogen synthase kinase 3 alpha | Homo sapiens |
| 2 | In addition, vinpocetine plus sorafenib activates glycogen synthase kinase 3beta (GSK-3beta) and subsequently inhibits cytoprotective autophagy induced by vinpocetine in HCC cells. | Sorafenib | glycogen synthase kinase 3 alpha | Homo sapiens |
| 3 | Meanwhile, overexpression of GSK-3beta was efficient to increase the apoptosis induced by vinpocetine plus sorafenib in HCC cells. | Sorafenib | glycogen synthase kinase 3 alpha | Homo sapiens |
| 4 | Our study revealed that vinpocetine plus sorafenib could suppress the cytoprotective autophagy induced by vinpocetine and subsequently show synergistically anti-HCC activity via activating GSK-3beta and the combination of vinpocetine and sorafenib might reverse sorafenib resistance via the PI3K/protein kinase B/GSK-3beta signaling axis. | Sorafenib | glycogen synthase kinase 3 alpha | Homo sapiens |
| 5 | Our study revealed that vinpocetine plus sorafenib could suppress the cytoprotective autophagy induced by vinpocetine and subsequently show synergistically anti-HCC activity via activating GSK-3beta and the combination of vinpocetine and sorafenib might reverse sorafenib resistance via the PI3K/protein kinase B/GSK-3beta signaling axis. | Sorafenib | glycogen synthase kinase 3 alpha | Homo sapiens |