Pub. Date : 2021 May 5
PMID : 33733573
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Toll-like receptor 4 is activated by platinum and contributes to cisplatin-induced ototoxicity. | Cisplatin | toll like receptor 4 | Homo sapiens |
| 2 | In this work, we test whether TLR4 can be activated by the Group 10 metal platinum and the platinum-based chemotherapeutic cisplatin. | Cisplatin | toll like receptor 4 | Homo sapiens |
| 3 | We demonstrate that platinum and cisplatin activate pathways downstream of TLR4 to a similar extent as the known TLR4 agonists LPS and nickel. | Cisplatin | toll like receptor 4 | Homo sapiens |
| 4 | We further show that TLR4 is required for cisplatin-induced inflammatory, oxidative, and cell death responses in hair cells in vitro and for hair cell damage in vivo. | Cisplatin | toll like receptor 4 | Homo sapiens |
| 5 | Finally, we identify a TLR4 small molecule inhibitor able to curtail cisplatin toxicity in vitro. | Cisplatin | toll like receptor 4 | Homo sapiens |