Title : Binding affinities of paclitaxel and docetaxel for generic and nanoparticle albumin-bound paclitaxel-derived albumin from human serum.

Pub. Date : 2021 Apr

PMID : 33732454






6 Functional Relationships(s)
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Protein Name
Organism
1 The high pressure employed during the manufacture of nab-paclitaxel HSA (nab HSA) may influence its conformation and/or oligomerization, and ultimately its affinity for HSA. nab albumin Homo sapiens
2 The high pressure employed during the manufacture of nab-paclitaxel HSA (nab HSA) may influence its conformation and/or oligomerization, and ultimately its affinity for HSA. nab albumin Homo sapiens
3 The high pressure employed during the manufacture of nab-paclitaxel HSA (nab HSA) may influence its conformation and/or oligomerization, and ultimately its affinity for HSA. nab albumin Homo sapiens
4 In the present study, nab HSA was isolated from nab-paclitaxel by gel filtration, and the binding affinities (KDs) were determined by surface plasmon resonance. nab albumin Homo sapiens
5 In the present study, nab HSA was isolated from nab-paclitaxel by gel filtration, and the binding affinities (KDs) were determined by surface plasmon resonance. nab albumin Homo sapiens
6 Paclitaxel showed KDs of 8.93+-8.60 and 7.39+-5.81 microM for nab HSA and control HSA, respectively, whereas the corresponding KDs for docetaxel were 44.3+-9.50 and 55.9+-2.28 microM, respectively. nab albumin Homo sapiens