Pub. Date : 2021 May 1
PMID : 33722665
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | NAM protects against cisplatin-induced acute kidney injury by suppressing the PARP1/p53 pathway. | Cisplatin | transformation related protein 53, pseudogene | Mus musculus |
| 2 | Here, we suggest that NAM may exert protective effects against cisplatin-induced acute kidney injury (AKI) mainly via suppressing the poly ADP-ribose polymerase 1 (PARP1)/p53 pathway. | Cisplatin | transformation related protein 53, pseudogene | Mus musculus |
| 3 | Mechanistically, NAM suppressed the expression and activation of p53, a known mediator of cisplatin-induced AKI. | Cisplatin | transformation related protein 53, pseudogene | Mus musculus |
| 4 | Thus, NAM may protect against cisplatin-induced AKI by suppressing the PARP1/p53 pathway. | Cisplatin | transformation related protein 53, pseudogene | Mus musculus |