Title : Discovery of GLPG1972/S201086, a Potent, Selective, and Orally Bioavailable ADAMTS-5 Inhibitor for the Treatment of Osteoarthritis.

Pub. Date : 2021 Mar 25

PMID : 33719441






1 Functional Relationships(s)
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1 We describe the discovery of GLPG1972/S201086, a potent and selective ADAMTS-5 inhibitor obtained by optimization of a promising hydantoin series following an HTS. Hydantoins ADAM metallopeptidase with thrombospondin type 1 motif 5 Homo sapiens